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Jean George Bachmann
(1877 – 1959)
French physician–physiologist whose experimental work in the early twentieth century provided the first clear functional description of a preferential interatrial conduction pathway. This structure, eponymically named “Bachmann’s bundle”, plays a central role in normal atrial activation and in the pathophysiology of interatrial block and atrial arrhythmias.
As a young man, Bachmann served as a merchant sailor, crossing the Atlantic multiple times. He emigrated to the United States in 1902 and earned his medical degree at the top of his class from Jefferson Medical College in Philadelphia in 1907. He stayed at this Medical College as a demonstrator and physiologist. In 1910, he joined Emory University in Atlanta. Between 1917 -1918 he served as a medical officer in the US Army. He retired from Emory in 1947 and continued his private medical practice until his death in 1959.
On the personal side, Bachmann was a man of many talents: a polyglot, he was fluent in German, French, Spanish and English. He was a chef in his own right and occasionally worked as a chef in international hotels. In fact, he paid his tuition at Jefferson Medical College, working both as a chef and as a language tutor.
The intrinsic cardiac conduction system was a major focus of cardiovascular research in the late nineteenth and early twentieth centuries. The atrioventricular (AV) node was discovered and described by Sunao Tawara and Karl Albert Aschoff in 1906, and the sinoatrial node by Arthur Keith and Martin Flack in 1907.
While the connections that distribute the electrical impulse from the AV node to the ventricles were known through the works of Wilhelm His Jr, in 1893 and Jan Evangelista Purkinje in 1839, the mechanism by which electrical impulses spread between the atria remained uncertain.
In 1916 Bachmann published a paper titled “The Inter-Auricular Time Interval” in the American Journal of Physiology. Bachmann measured activation times between the right and left atria and demonstrated that interruption of a distinct anterior interatrial muscular band resulted in delayed left atrial activation. He concluded that this band constituted the principal route for rapid interatrial conduction.
Subsequent anatomical and electrophysiological studies confirmed the importance of the structure described by Bachmann, which came to bear his name. Bachmann’s bundle is now recognized as a key determinant of atrial activation patterns, and its dysfunction is associated with interatrial block, atrial fibrillation, and abnormal P-wave morphology. His work remains foundational in both basic cardiac anatomy and clinical electrophysiology.
Sources and references
1. Bachmann G. “The inter-auricular time interval”. Am J Physiol. 1916;41:309–320.
2. Hurst JW. “Profiles in Cardiology: Jean George Bachmann (1877–1959)”. Clin Cardiol. 1987;10:185–187.
3. Lemery R, Guiraudon G, Veinot JP. “Anatomic description of Bachmann’s bundle and its relation to the atrial septum”. Am J Cardiol. 2003;91:148–152.
4. "Remembering the canonical discoverers of the core components of the mammalian cardiac conduction system: Keith and Flack, Aschoff and Tawara, His, and Purkinje" Icilio Cavero and Henry Holzgrefe Advances in Physiology Education 2022 46:4, 549-579.
5. Knol WG, de Vos CB, Crijns HJGM, et al. “The Bachmann bundle and interatrial conduction” Heart Rhythm. 2019;16:127–133.
6. “Iatrogenic biatrial flutter. The role of the Bachmann’s bundle” Constán E.; García F., Linde, A.. Complejo Hospitalario de Jaén, Jaén. Spain
7. Keith A, Flack M. The form and nature of the muscular connections between the primary divisions of the vertebrate heart. J Anat Physiol 41: 172–189, 1907.
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The anatomical, term [buccinator] refers to a quadrilateral muscle that forms the side of the mouth and the face, vernacularly known as “mouth cheeks”.
Its origin is from the Latin word [bucca] meaning mouth (in Spanish the term meaning mouth is "boca"). Further evolution of the word leads to the Latin term [buccina] meaning “trumpet” or “horn”, and [buccinator] which means “trumpeter”
The term takes real meaning when you look at a trumpet player distending the buccinator muscle to obtain longer note, such as the well-known Louis Armstrong or Dizzy Gillespie. (see image).
For the anatomical description of this muscle, click here
Image source: By Roland Godefroy - Own work, CC BY 3.0, https://commons.wikimedia.org/w/index.php?curid=4612877
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While working on my library catalog, I made a very nice discovery!
I found a set of 22 medical brochures circa 1950, from MedExport, an USSR government-sponsored company. These brochures depict instruments that are not in use now, or have been modernized.
The brochures were inside one of the books that Dr. Mark Ravitch's family donated to my library.
Some of these are surgical staplers which I have mentioned in my series of articles "History of Surgical Stapling" which includes a video on the topic.
What is interesting is that some of these instruments where discarded and thought of as non-practical, but they are coming back in modern versions such as the coronary artery bypass graft (CABG) vascular devices manufactured by Cardica, a division of Dextera Surgical.
An example of this is shown in the image attached to this article (you can click on the image for a larger view).
This is the YAN-30, used to close the ductus arteriosus, also known as the Duct of Botallus, named after Leonardo Botallus.
This duct has a function in the fetus, and it closed shortly after birth. Patency of the ductus arteriosus causes deoxygenated blood to mix with the oxygenated blood in the thoracic aorta giving rise to a condition known as PDA or Patent Ductus Arteriosus.
Needless to say, I am not selling or trading these priceless collector's items!!
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This article is part of the series "A Moment in History" where we honor those who have contributed to the growth of medical knowledge in the areas of anatomy, medicine, surgery, and medical research.
Henry J. Heimlich, MD (1920 - 2016). A thoracic surgeon, Dr. Henry J. Heimlich was born in 1920 in Wilmington, DE; and died in Cincinnati on December 17, 2016. He studied Medicine at Cornell University and served in the US Naval Reserve. In the early 1960's he designed a one-way valve to allow for the slow drainage of a pneumothorax or a pneumohemothorax. He is best known for the creation and world-wide known "Heimlich maneuver" to clear the upper respiratory pathways in the case of choking victims.
In 1969 Dr. Heimlich became director of surgery at the Jewish Hospital in Cincinnati, he was also a professor of clinical sciences at the Xavier University in Cincinnati and president of his namesake Institute.
Sadly, the memory of Dr. Heimlich is slowly dissapearing, as the Deaconess Institute no longer publishes the pages for the Heimlich maneuver and his biography. The Internet Archive still maintains a copy of this website here. More information can be found on Wikipedia.
Although it is our policy to not provide personalized medical information, here is a website where you can read about how to perform the Heimlich Maneuver.
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This is a series of articles on depression and published as a community service. The information in these articles follow our Privacy and Security Guidelines and cannot be construed as medical guidance. For additional information and counseling, consult with your physician or the appropriate health care professional of your choice. You can also find information on Transcranial Magnetic Stimulation (TMS) here. For the initial article on this series click here.
There are several forms of depressive disorders.
• Major depression: Characterized by the presence of severe symptoms that interfere with the individual's ability to work, sleep, study, eat, and enjoy life. An episode can occur only once in a lifetime, but more often, a person has several episodes separated by varying lengths of time.
• Persistent depressive disorder: Also known as Major Depressive Disorder (MDD) it is a depressed mood that lasts for at least 2 years. A person diagnosed with persistent depressive disorder may have episodes of major depression along with periods of less severe symptoms, but in general the depressive mood lasts for a minimum of 2 years. In both cases, patients present with depressed mood, loss of interest or pleasure, decreased energy, feelings of guilt or low self-worth, abnormal patterns of sleep or appetite, gruesome nightmares, and poor concentration.
Some forms of depression are slightly different, or they may develop under unique circumstances. They include:
• Psychotic depression: Psychotic depression occurs when a person has severe depression plus some form of psychosis, such as having disturbing false beliefs or a break with reality (delusions), or hearing or seeing upsetting things that others cannot hear or see (hallucinations).
• Postpartum depression: This is much more serious than the "baby blues" that many women experience after giving birth, when hormonal and physical changes and the new responsibility of caring for a newborn can be overwhelming. It is estimated that 10 to 15 percent of women experience postpartum depression after giving birth. There is a rare variant of this disorder, the prepartum depression, which as the name implies happens in the final stages of pregnancy. In both these cases the problem is that the patient cannot be treated with drugs as they may affect the fetus, or the patient cannot breast-feed the newborn eliminating an important stage in the mother-child bonding process. A depressed mother with drug therapy and concurrent side-effects may not able to care for her baby. Thia patient is a good candidate for TMS.
• Seasonal affective disorder (SAD): Is characterized by the onset of depression during the winter months, when there is less natural sunlight. The depression generally lifts during spring and summer. SAD may be effectively treated with light therapy, but nearly half of those with SAD do not get better with light therapy alone. Antidepressant medication and psychotherapy can reduce SAD symptoms, either alone or in combination with light therapy. In some patients the onset of SAD can be the trigger for MDD.
• Bipolar disorder: Also called manic-depressive illness, is not as common as major depression or persistent depressive disorder. Bipolar disorder is characterized by cycling mood changes that range from extreme highs (e.g., mania) to extreme lows (e.g., depression).
References:
1. Altshuler LL, Hendrich V, Cohen LS. Course of mood and anxiety disorders during pregnancy and the postpartum period. Journal of Clinical Psychiatry, 1998; 59:29.
2. Rohan KJ, Lindsey KT, Roecklein KA, Lacy TJ. Cognitive-behavioral therapy, light therapy and their combination in treating seasonal affective disorder. Journal of Affective Disorders, 2004; 80:273–283.XX
Next: Treatment options
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The medical term [ictal] arises from the Latin word [ictus] meaning a "a blow, strike, stroke, or thrust," and [icere] meaning "to strike, to hit," also related to [iæcere], meaning "to throw". The root term is [ict-] and with the adjectival suffix [-al] means “pertaining to a blow or stroke”.
The use of the term [ictus] today refer to a sudden onset of medical or physiological event such as a seizure, stroke, headache, or migraine.
Associated terms are:
[Preictal] (sometimes written pre-ictal) meaning “before the blow or stroke” and usually refers to symptoms or signs that precede or are at the beginning of the ictus. These symptoms are also called a [prodrome].
[Postictal] (sometimes written post-ictal) meaning “after the blow or stroke” and refers to the period immediately after the ictus where the symptoms and signs are receding.
In the case of an epileptic seizure the [postictal state] is the altered state of consciousness after the seizure, and is characterized by drowsiness, confusion, nausea, hypertension, headache or migraine, and can be followed by amnesia.
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The following article was published by Theo Dirix in his blog. He is one of the Vesalius Continuum project members and a contributor to this website. Theo Dirixis an author and a taphophile. He has successively held the office of Consul in Embassies of Belgium in Tanzania, Saudi Arabia, Jordan, Canada, the United Arab Emirates and, since 2011, Greece. His current posting is in Kopenhagen, Denmark Before 1989, he worked for the Flemish Radio 3 and commented on (mainly Moroccan) literature. He is constantly writing travel stories of his visits to cemeteries and graves. He is also the author of the book "In Search of Andreas Vesalius: The Quest for the Lost Grave".
“Andreas Vesalius is a rock star in well defined circles”, a friend wrote to me in an e-mail and: ”I hate disappointing people". That is to say with the results of the upcoming crucial phase in the search for his lost grave in Zakynthos, Greece. I guess she considers all 800 friends of my Vesalius Continuum Page as members of those "well defined circles". Let me assure her, and all of you, Vesalius groupies, that nobody will be disappointed.
Potential sponsors definitely won’t. They just have to ask Agfa HealthCare Greece, that has financed the Geographical Information System of the first phase. With the amount paid, a company cannot even buy a single add in a newspaper; Agfa got dozens of adds instead, during our talks, in publications and in this paragraph.
Neither will Vesalius groupies, even after a generous contribution to the crowd funding campaign. Beyond the pleasure of discovering a geophysical prospection, they can bid on the miniature facial reconstruction we will present here soon. Or on paintings of skulls, cells and blood; one of my mentors is already labeling his acrylic studies we will auction soon.
And finally, no scientist will. Of course, there are some who will grin if we find ... nothing, but they seem to forget that a non-discovery can be as important as a find. Many more, however, continue to encourage us. They know funerary slabs have already been found under the corner house of Kolyva/Kolokotroni in the city center, where we concentrate our search. I’ll never forget the reaction of an archaeologist when I showed her the pictures of those artefacts in Pavlos Plessas’s blog.
From pampalaia.blogspot.dk/2012/08/blog-post.html I quote:
"How many excavations would you say have taken place at this site, which could, and should, have been the focus of a universal cultural pilgrimage? As far as I know none! Unless of course the dynamites and the bulldozers that after the catastrophic earth-quakes of 1953 demolished any wall left standing and pushed it into the sea can be thought of as an archaeological dig."
Back to our plans: a team of four or five researchers will walk through that part of the town with a Ground Penetrating Radar device. They will drill small holes (of about one cm in diameter and twenty cm in depth) in the asphalt roads, pavements and surroundings to enter electrodes and carry out the Electrical Resistivity Tomography. To get permits for making the holes, have plans of any utility networks and carry out the fieldwork, this geophysical prospection will take five days maximum. After processing the survey, the research center IMS/FORTH, Rethymnon, will come up with a map of underground architectural remains.
How exiting is that? I'm looking forward to receiving your comments. Are you ready to register, to pledge your support ?
Personal note: Click on the following link to collaborate with this incredible quest. I already did. Dr. Miranda
GoFundMe Campaign for the next stage of the project






