Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

Andreas Vesalius Bruxellensis (1514- 1564)

A Flemish anatomist and surgeon, Andreas Vesalius was born on December 31, 1514 in Brussels, Belgium. He is considered to be the father of the science of Anatomy. Up until his studies and publications human anatomy studies consisted only on the confirmation of the old doctrines of Galen of Pergamon (129AD - 200AD). Anatomy professors would read to the students from Galen's work and a demonstrator would point in a body to the area being described, if a body was used at all. The reasoning was that there was no need to dissect since all that was needed to know was already written in Galen's books. Vesalius, Fallopius, and others started the change by describing what they actually saw in a dissection as opposed to what was supposed to be there. 

Vesalius had a notorious career, both as an anatomist and as a surgeon. His revolutionary book "De Humani Corporis Fabrica: Libri Septem" was published in May 26, 1543. One of the most famous anatomical images is his plate 22 of the book, called sometimes "The Hamlet". You can see this image if you hover over Vesalius' only known portrait which accompanies this article. Sir William Osler said of this book "... it is the greatest book ever printed, from which modern medicine dates" 

After the original 1543 printing, the Fabrica was reprinted in 1555. It was re-reprinted and translated in many languages, although many of these printings were low-quality copies with no respect for copyright or authorship.

The story of the wood blocks with the carved images used for the original printing extends into the 20th century. In 1934 these original wood blocks were used to print 617 copies of the book "Iconaes Anatomica". This book is rare and no more can be printed because, sadly, during a 1943 WWII bombing raid over Munich all the wood blocks were burnt.

One interesting aspect of the book was the landscape panorama in some of his most famous woodcuts which was only "discovered" until 1903.

Vesalius was controversial in life and he still is in death. We know that he died on his way back from a pilgrimage to Jerusalem, but how he died, and exactly where he died is lost in controversy. We do know he was alive when he set foot on the port of Zakynthos in the island of the same name in Greece. He is said to have suddenly collapsed and die at the gates of the city, presumably as a consequence of scurvy. Records show that he was interred in the cemetery of the Church of Santa Maria delle Grazie, but the city and the church were destroyed by an earthquake and Vesalius' grave lost to history. Modern researchers are looking into finding the lost grave and have identified the location of the cemetery. This story has not ended yet.

For a detailed biography of Andreas Vesalius CLICK HERE.

Personal note: To commemorate Andrea Vesalius' 500th birthday in 2014, there were many scientific meetings throughout the world, one of them was the "Vesalius Continuum" anatomical meeting on the island of Zakynthos, Greece on September 4-8, 2014. This is the island where Vesalius died in 1564. I had the opportunity to attend and there are several articles in this website on the presence of Andreas Vesalius on Zakynthos island. During 2015 I also attended a symposium on "Vesalius and the Invention of the Modern Body" at the St. Louis University. At this symposium I had the honor of meeting of Drs. Garrison and Hast, authors of the "New Fabrica". Dr. Miranda


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Pisiform

Pisiform - anterior (volar) view of the wrist
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The pisiform bone is one of the four bones that comprise the proximal row of the carpus or carpal bones that form the wrist. It is the smallest of the carpal bones, is spheroidal in shape, and presents with only one articular surface (see image).

Its name originates from the Latin [pisum], meaning "pea". It is also known as "os pisiforme" or "lentiform bone", because some feel it is shaped like a lentil.

The pisiform bone articulates posteriorly with the triquetrum, and has on its anterior (volar) surface attachments to the transverse carpal ligament, and to the Abductor Digiti Quinti, and Flexor Carpi Ulnaris muscles.

The accompanying image shows the anterior (volar) surface of the wrist.

Image modified from the original: "3D Human Anatomy: Regional Edition DVD-ROM." Courtesy of Primal Pictures


Fossa

This is a Latin word meaning a trench, a ditch, or an excavation. It arises from the Latine term [fodere] meaning "to dig". The plural form for "fossa" is "fossae".

There are many fossae listed in human anatomy, here are some of them:

  • fossa scaphoides: found in the pinna
  • fossa ovalis: found in the wall of the right atrium
  • fossa triangularis: found in the pinna
  • ischioanal fossa: a triangular fossa found in the perineum, inferior to the pelvic diaphragm and superior to the urogenital diaphragm, etc.

Pre-

The prefix [pre-] has its origin in the Latin preposition [prae] meaning "anterior", "in front of", or "before". 

Applications of this prefix include:

  • precordial: anterior to the heart, as in "precordial pain"
  • preoperative: before the operation
  • preperitoneal: anterior to the peritoneum, referring to the region found outside and anterior to the peritoneal sac, an area containing fat, and important for preperitoneal laparoscopic surgery
  • presystolic: before systole
  • preaortic: anterior to the aorta

Posterior interventricular artery

Posteroinferior view of the heart. IVC=inferior Vena Cava
Click for a larger image

The right coronary artery usually bifurcates in an area of the posterior aspect of the heart known as the "crux cordis" giving origin to two terminal branches: the posterior interventricular artery (anatomical term) and the posterolateral artery. The posterior interventricular artery is better know to clinicians as the "posterior descending artery" or PDA.

The PDA descends towards the apex cordis where it ends. It gives off several small ventricular branches, but its most important branches are the septal perforators. These branches dive deep and provide blood supply to the posterior 1/3rd of the interventricular septum.

The AV node artery, which provides blood supply to the AV node (a component of the conduction system of the heart) may arise from the PDA instead of arising from the right coronary artery.

The PDA may present with a number of anatomical variations, including:

  • arising from the circumflex artery (and absence of the posterolateral artery)
  • arising from the first septal perforator of the anterior interventricular artery
  • arising from the second diagonal artery
  • arising from anterior interventricular artery
  • being double, with one PDA arising from the circumflex artery, and another from the right coronary artery, etc.

Image property of: CAA, Inc. Photographer: E. Klein


Sunao Tawara, M.D.

This article is part of the series "A Moment in History" where we honor those who have contributed to the growth of medical knowledge in the areas of anatomy, medicine, surgery, and medical research.

Sunao Tawara, M.D.
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Sunao Tawara, M.D. (1873 - 1952) Sunao Tawara was born in the prefecture of Ooita, Kyushu, Japan. Adopted by an uncle (and physician), Tawara studied English and German, and went on to the University of Tokyo medical school, where he graduated an MD in 1901.

In 1903 he traveled to Marburg, Germany, where he started working with Dr. Karl Albert Ludwig Aschoff (1866-1942), a noted pathologist. Tawara’s work led him to the discovery of what today we call the “atrioventricular node” (AV node) and the connections of the AV node and the Bundle of His (the right and left bundle branch). His work with Aschoff led to the eponym of “node of Aschoff-Tawara” for the AV node. Tawara’s work also led to the understanding of the function of the Purkinje fibers. Tawara gave the entire system the name “Reitzleitungssytem” or the “conduction system” of the heart.

In 1906 Dr. Tawara published his discoveries in a German-language article entitled “The Conduction System of the Mammalian Heart — An Anatomicopathological Study on the Atrioventricular Bundle and the Purkinje Fibers”. The same year he returned to Japan and in 1908 became Professor of Pathology at the University of Kyushu until his retirement in 1933.

Sources:
1. "Sunao Tawara" Suma, K. Clin Cardiol (1991) 14; 442-443
2. "Sunao Tawara, A Cardiac Pathophysiologist" Loukas, M. et al Clinical Anatomy 21:2–4 (2008)
3. "Sunao Tawara: A Father of Modern Cardiology" Suma, K. J Pacing Clin Electrophysiol (2001) 24:1; 88- 96


Circumflex artery

Coronary Arteries. The [*] indicates the left coronary artery
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The [circumflex artery]  (CFX) is one of the two branches of the left coronary artery, the other one being the left anterior descending artery (LAD), also known as the anterior interventricular artery.

The prefix [circum-] means "around", while the root term [-flex-] means "to bend". This describes quite well the circumflex artery, which "bends around" the obtuse margin of the heart passing from the anterior surface to the posterior surface of the heart.

The circumflex artery lies deep to the epicardium in the subepicardial fatty layer. It gives off several branches, including small left atrial branches and one or two obtuse marginal arteries (OM1 and OM2)that provide blood supply to the left ventricle in its obtuse margin and posterior ventricular region, as well as a portion of the anterior papillary muscle related to the mitral valve.

There can be interesting anatomical variations in the coronary arteries of the heart. For a detail on these anatomical variations, click here. Heart and coronary artery anatomy is one of the many lecture topics presented by CAA, Inc.

Image property of:CAA.Inc.Artist:Victoria G. Ratcliffe