Medical Terminology Daily - Est. 2012

Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

Georg Eduard Von Rindfleisch

Georg Eduard Von Rindfleisch
(1836 – 1908)

German pathologist and histologist of Bavarian nobility ancestry. Rindfleisch studied medicine in Würzburg, Berlin, and Heidelberg, earning his MD in 1859 with the thesis “De Vasorum Genesi” (on the generation of vessels) under the tutelage of Rudolf Virchow (1821 - 1902). He then continued as a assistant to Virchow in a newly founded institute in Berlin. He then moved to Breslau in 1861 as an assistant to Rudolf Heidenhain (1834–1897), becoming a professor of pathological anatomy. In 1865 he became full professor in Bonn and in 1874 in Würzburg, where a new pathological institute was built according to his design (completed in 1878), where he worked until his retirement in 1906.

He was the first to describe the inflammatory background of multiple sclerosis in 1863, when he noted that demyelinated lesions have in their center small vessels that are surrounded by a leukocyte inflammatory infiltrate.

After extensive investigations, he suspected an infectious origin of tuberculosis - even before Robert Koch's detection of the tuberculosis bacillus in 1892. Rindfleisch 's special achievement is the description of the morphologically conspicuous macrophages in typhoid inflammation. His distinction between myocardial infarction and myocarditis in 1890 is also of lasting importance.

Associated eponyms

"Rindfleisch's folds": Usually a single semilunar fold of the serous surface of the pericardium around the origin of the aorta. Also known as the plica semilunaris aortæ.

"Rindfleisch's cells": Historical (and obsolete) name for eosinophilic leukocytes.

Personal note: G. Rindfleisch’s book “Traité D' Histologie Pathologique” 2nd edition (1873) is now part of my library. This book was translated from German to French by Dr. Frédéric Gross (1844-1927) , Associate Professor of the Medicine Faculty in Nancy, France. The book is dedicated to Dr. Theodore Billroth (1829-1894), an important surgeon whose pioneering work on subtotal gastrectomies paved the way for today’s robotic bariatric surgery. Dr. Miranda.

Sources:
1. "Stedmans Medical Eponyms" Forbis, P.; Bartolucci, SL; 1998 Williams and Wilkins
2. "Rindfleisch, Georg Eduard von (bayerischer Adel?)" Deutsche Biographie
3. "The pathology of multiple sclerosis and its evolution" Lassmann H. (1999)  Philos Trans R Soc Lond B Biol Sci. 354 (1390): 1635–40.
4. “Traité D' Histologie Pathologique” G.E.
Rindfleisch 2nd Ed (1873) Ballieres et Fils. Paris, Translated by F Gross


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Homeostasis

Homeostasis is the coordinated set of physiological mechanisms that preserve a stable internal bodily environment (through feedback-controlled regulatory processes) despite fluctuations in the external environment. The concept applies to many dynamic regulations of physiological variables such as body temperature, pH, electrolyte balance, osmolarity, blood glucose, etc.

Claude Bernard (1813–1878) introduced the concept of a “milieu intérieur” the “internal environment” in 1865 where he stated “La fixité du milieu intérieur est la condition de la vie libre et indépendante.” (The constancy of the internal environment is the condition for a free and independent life). Walter B. Cannon (1871–1945) formally coined the term homeostasis in 1929. In his reasoning to name these processes under one name he used the Greek term "ομοιόσταση" [omeóstasí) meaning "constant & stable" or "similar & standing still" referring to a constant (internal) environment.

Disruption of homeostatic processes can contribute to disease states such as diabetes mellitus (failure of glucose homeostasis), heart failure (impaired circulatory stability), heat stroke and/or hypothermia (thermoregulatory failure), hyponatremia or hypernatremia (electrolyte imbalance), etc.

For additional information here is an article from the National Library of Medicine.

Sources
1. Claude Bernard, "Introduction à l’étude de la médecine expérimentale" (1865). 
2. “Organization for physiological homeostasis” Cannon W. B.; Physiol Rev. 1929; 9:399–431.
3. "Textbook of Medical Physiology"; Guyton, Arthur C and Hall, John E ISBN: 0721659446 USA: W.B. Saunders, 1996.
4. “Homeostasis and Body Fluid Regulation: An End Note”. De Luca LA Jr, David RB, Menani JV. Neurobiology of Body Fluid Homeostasis: Transduction and Integration. Boca Raton (FL): CRC Press/Taylor & Francis; 2014. Chapter 15