Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

Andreas Vesalius Bruxellensis (1514- 1564)

A Flemish anatomist and surgeon, Andreas Vesalius was born on December 31, 1514 in Brussels, Belgium. He is considered to be the father of the science of Anatomy. Up until his studies and publications human anatomy studies consisted only on the confirmation of the old doctrines of Galen of Pergamon (129AD - 200AD). Anatomy professors would read to the students from Galen's work and a demonstrator would point in a body to the area being described, if a body was used at all. The reasoning was that there was no need to dissect since all that was needed to know was already written in Galen's books. Vesalius, Fallopius, and others started the change by describing what they actually saw in a dissection as opposed to what was supposed to be there. 

Vesalius had a notorious career, both as an anatomist and as a surgeon. His revolutionary book "De Humani Corporis Fabrica: Libri Septem" was published in May 26, 1543. One of the most famous anatomical images is his plate 22 of the book, called sometimes "The Hamlet". You can see this image if you hover over Vesalius' only known portrait which accompanies this article. Sir William Osler said of this book "... it is the greatest book ever printed, from which modern medicine dates" 

After the original 1543 printing, the Fabrica was reprinted in 1555. It was re-reprinted and translated in many languages, although many of these printings were low-quality copies with no respect for copyright or authorship.

The story of the wood blocks with the carved images used for the original printing extends into the 20th century. In 1934 these original wood blocks were used to print 617 copies of the book "Iconaes Anatomica". This book is rare and no more can be printed because, sadly, during a 1943 WWII bombing raid over Munich all the wood blocks were burnt.

One interesting aspect of the book was the landscape panorama in some of his most famous woodcuts which was only "discovered" until 1903.

Vesalius was controversial in life and he still is in death. We know that he died on his way back from a pilgrimage to Jerusalem, but how he died, and exactly where he died is lost in controversy. We do know he was alive when he set foot on the port of Zakynthos in the island of the same name in Greece. He is said to have suddenly collapsed and die at the gates of the city, presumably as a consequence of scurvy. Records show that he was interred in the cemetery of the Church of Santa Maria delle Grazie, but the city and the church were destroyed by an earthquake and Vesalius' grave lost to history. Modern researchers are looking into finding the lost grave and have identified the location of the cemetery. This story has not ended yet.

For a detailed biography of Andreas Vesalius CLICK HERE.

Personal note: To commemorate Andrea Vesalius' 500th birthday in 2014, there were many scientific meetings throughout the world, one of them was the "Vesalius Continuum" anatomical meeting on the island of Zakynthos, Greece on September 4-8, 2014. This is the island where Vesalius died in 1564. I had the opportunity to attend and there are several articles in this website on the presence of Andreas Vesalius on Zakynthos island. During 2015 I also attended a symposium on "Vesalius and the Invention of the Modern Body" at the St. Louis University. At this symposium I had the honor of meeting of Drs. Garrison and Hast, authors of the "New Fabrica". Dr. Miranda


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Luigi A. Galvani

This article is part of the series "A Moment in History" where we honor those who have contributed to the growth of medical knowledge in the areas of anatomy, medicine, surgery, and medical research.

Luigi Galvani
Luigi Galvani

Luigi A. Galvani (1737-1798). Italian anatomist, surgeon, and physiologist, Luigi Aloisio Galvani was born in Bologna in 1737. Although he started his studies to join the church, Galvani followed with medical studies at the University of Bologna, where he became a skilled anatomist and surgeon. On July 15, 1759 Galvani obtained his degree in medicine and philosophy.

He was interested in the effects of electricity on tissues and through observation and experimentation he postulated the existence of "animal electricity", that is, electricity generated within the tissues. He postulated the possibility that nerves carried electricity. His theories led to a passionate controversy with Volta, who denied Galvani's postulates. Galvani's theories would only be confirmed after his death. 

Galvani was deeply religious, and when forced by government officials to take an oath of atheism, he refused. He was stripped of his position and was lead to poverty. His position was restored close to his death. In his honor, Andre Ampere (1775-1836) named one of his inventions that measures electricity,  the "galvanometer". His name is also present in vernacular English, when we say that a rock star or a movie "galvanizes" an audience, meaning it was "electrifying"!

Sources:
1. "Luigi Galvani" Haas LF J Neurol Neurosurg Psychiatry v.56(10); Oct 1993
2. "Luigi Galvani and the foundations of electrophysiology" Cajavilca C, Varonb,J,Sternbachc GL; Resuscitation 80 (2009) 159–162


Capitate

Capitate bone - anterior (volar) view of the wrist
Click for a larger image

The capitate bone is one of the four bones that comprise the distal row of the carpus or carpal bones that form the wrist. It is the largest of the carpal bones and is placed in the center of the wrist (see image).

Its name originates from the Latin [caput], meaning "head". The capitate bone presents a large, rounded area, called the "head". To complete the homology, the capitate bone also has a narrow segment called the "neck", the rest of the bone called the "body". It is also known as "os capitatum" or "os magnum"

The capitate bone articulates with seven bones, including the scaphoid, lunate, trapezoid, hamate, and the three central metacarpals (2nd, 3rd, and 4th).

The accompanying image shows the anterior (volar) surface of the wrist.

Image modified from the original: 3D Human Anatomy: Regional Edition DVD-ROM" Courtesy of Primal Pictures


Duodenum

Retroperitoneal organs
Click for a larger image

The duodenum is a mostly retroperitoneal organ, part of the digestive tract, and the most proximal portion of the small intestine. This organ is approximately 10 inches in length (24.5 cm). It starts at the pylorus of the stomach, has a "C" shape, curving around the head and the neck of the pancreas, to end at the duodenojejunal junction.

The duodenum is described as having four segments of differing length, usually named numerically:

  • First segment: about two inches in length, it is dilated and called the "duodenal ampulla", or "superior duodenum"
  • Second segment: about three inches in length, it receives bile and pancreatic juice through the hepatopancreatic ducts and ampullae. It is also called the "descending duodenum"
  • Third segment: about four inches in length, it crosses the midline, and is also known as the "horizontal" or "transverse duodenum"
  • Fourth segment: one inch in length, this is the shortest segment, it ascends towards the duodenojejunal junction, which is tethered to the diaphragm by a fold of peritoneum around a fibromuscular band called the "ligament of Treitz". At this point the retroperitoneal duodenum becomes the intraperitoneal jejunum. This fourth segment is also called the "ascending duodenum"

The name of the organ is interesting. Most textbooks claim that is originates from the Latin [duodeni], meaning "twelve". The fact is that the duodenum was originally named in Greek [δώδεκα δάχτυλαν] meaning "twelve fingers". If you place both your hands together and add 1/4 of an inch to each side (as if you had an extra finger on each hand) that measures approximately 10 inches. The term was shortened by an incorrect translation to "twelve" by Gerard of Cremona (1114 - 1187) who called it "duodenum", a bad translation, as twelve fingers in Latin is [duodecim digitorum].

While most of the duodenum is retroperitoneal, the first inch of the superior duodenum (first segment) is intraperitoneal as it shares a small portion of the lesser omentum with the stomach and liver.

Sources:
1.
"Clinically Oriented Anatomy" Moore, KL. 3r Ed. Williams & Wilkins 1992
2. "The origin of Medical Terms" Skinner, AH, 1970 
Image property of: CAA, Inc. Artist: Dr. E. Miranda


Brady-

This prefix is derived from the Greek and means "slow". Most everybody knows about [bradycardia] meaning "slow heart", but there is a large number of applications of this prefix as follows:

  • Bradytrophia: from the Greek [trophe] meaning "to feed" or "nutrition". Braditrophia is a slow nutritional process
  • Bradypnea: from the Greek [pnoia], meaning "breath" or "air". Bradypnea is an abnormally slow breathing rhythm
  • Bradylalia: from the Greel [lalein] meaning "to talk". Bradylalia is a slow articulation or formation of words, sometimes also known as [bradyarthria] or [bradyphasia]. See the article on aphasia and dysphasia here
  • Bradykinesia: from the Greek [kinesis], meaning "movement". Bradykinesia means "slow movement", also known as [bradypragia]
  • Bradycrotic: from the Greek [krotos], meaning "pulse" "or pulsation" A bradycrotic agent slows down the patient's pulse or heart rate.
  • Bradytocia: from the Greek [tokos], meaning "birth". Bradytocia is a slow birthing process

Bregma

Superior view of the cranium
Click for a larger image

The word [bregma] is Greek and means "the front of the head". It is actually the point of intersection of the the coronal and sagittal sutures. The coronal suture is the articulation or joint between the frontal and parietal bones, and the sagittal suture is the median joint between both parietal bones. 

The term was first used in anatomy as a craniometric point by Paul Broca (1824 - 1880). The image shows a superior view of two heads and the location of the coronal and sagittal sutures. The bregma is the point of intersection of these two articulations.

Click on the image for a larger view. 1 = coronal suture 2 = sagittal suture 3 = lambdoid suture. The bregma is the point of intersection of 1 and 2

Original image courtesy of Wikipedia


Marie-Francois Xavier Bichat

This article is part of the series "A Moment in History" where we honor those who have contributed to the growth of medical knowledge in the areas of anatomy, medicine, surgery, and medical research.

Marie_Francois Xavier Bichat
Original image courtesy of
Images from the History of Medicine

Marie-Francois Xavier Bichat
(1771 - 1802). French physician, surgeon, anatomist and physiologist, Marie-Francois Xavier Bichat was born in the village of Thoirette. His father was a physician, influencing his early instruction and vocation. In Lyon he studied anatomy and surgery. At 28 years of age Bichat was appointed physician to the Hôtel (Hospital) Dieu. His life was influenced by his mentor, Pierre-Joseph Dassault (1738 - 1795). Upon his mentor's death Bichat took upon him to continue and finish his work, while supporting his mentor's family.

Bichat is know for the concept of the body composed of distinct tissues, which he originally called "membranes". Without the aid of the microscope Bichat described 21 different tissues and is considered the founder of the science of histology. His name is preserved in many eponymic structures such as Bichat’s fossa (pterygopalatine fossa), Bichat’s buccal fat pad, Bichat’s foramen (cistern of the vena magna of Galen), Bichat’s ligament (lower fasciculus of the posterior sacroiliac ligament), and Bichat’s tunica intima (tunica intima vasorum). 

Xavier Bichat also contributed to a newer description of the humoral physiological theory, later becoming the basis of hematology. He was also interested in the description of life and death, proposing the existence of an "organic life" and an "animal life". An interesting note is that Bichat died because of an infection he acquired while dissecting a cadaver. Remember that at the time, no embalming was used!

Today Bichat's name is almost forgotten, although in some countries the buccal fat pad is still called "Bichat's fat pad" In many Spanish-speaking countries this structure is referred to as "la bola grasa de Bichat", and many still refer to the removal of this fat pad as "Bichectomy". For an image of the before and after of the procedure, click here.

Sources:
1. "Marie-Fran?ois Xavier Bichat (1771-1802) and his contributions to the foundations of pathological anatomy and modern medicine" Shoja M.M., Tubbs R.S., Loukas M., Shokouhi G., Ardalan M.R.(2008) Annals of Anatomy, 190(5),413-420
2. "Physiological Researches on Life and Death" Bichat, Marie-Francois Xavier, 1827. Translated from French by F. Gold. Richardson and Lord, Boston.
3. "A Historical Perspective: Infection from Cadaveric Dissection from the 18th to the 20th Centuries" Shoja, MM et al. Clin Anat (2013) 26:154-160