Thebesian valve

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A Moment in History

Georg Eduard Von Rindfleisch
(1836 – 1908)

German pathologist and histologist of Bavarian nobility ancestry. Rindfleisch studied medicine in Würzburg, Berlin, and Heidelberg, earning his MD in 1859 with the thesis “De Vasorum Genesi” (on the generation of vessels) under the tutelage of Rudolf Virchow (1821 - 1902). He then continued as a assistant to Virchow in a newly founded institute in Berlin. He then moved to Breslau in 1861 as an assistant to Rudolf Heidenhain (1834–1897), becoming a professor of pathological anatomy. In 1865 he became full professor in Bonn and in 1874 in Würzburg, where a new pathological institute was built according to his design (completed in 1878), where he worked until his retirement in 1906.

He was the first to describe the inflammatory background of multiple sclerosis in 1863, when he noted that demyelinated lesions have in their center small vessels that are surrounded by a leukocyte inflammatory infiltrate.

After extensive investigations, he suspected an infectious origin of tuberculosis - even before Robert Koch's detection of the tuberculosis bacillus in 1892. Rindfleisch 's special achievement is the description of the morphologically conspicuous macrophages in typhoid inflammation. His distinction between myocardial infarction and myocarditis in 1890 is also of lasting importance.

Associated eponyms

"Rindfleisch's folds": Usually a single semilunar fold of the serous surface of the pericardium around the origin of the aorta. Also known as the plica semilunaris aortæ.

"Rindfleisch's cells": Historical (and obsolete) name for eosinophilic leukocytes.

Personal note: G. Rindfleisch’s book “Traité D' Histologie Pathologique” 2nd edition (1873) is now part of my library. This book was translated from German to French by Dr. Frédéric Gross (1844-1927) , Associate Professor of the Medicine Faculty in Nancy, France. The book is dedicated to Dr. Theodore Billroth (1829-1894), an important surgeon whose pioneering work on subtotal gastrectomies paved the way for today’s robotic bariatric surgery. Dr. Miranda.

Sources:
1. "Stedmans Medical Eponyms" Forbis, P.; Bartolucci, SL; 1998 Williams and Wilkins
2. "Rindfleisch, Georg Eduard von (bayerischer Adel?)" Deutsche Biographie
3. "The pathology of multiple sclerosis and its evolution" Lassmann H. (1999) Philos Trans R Soc Lond B Biol Sci. 354 (1390): 1635–40.
4. “Traité D' Histologie Pathologique” G.E.
Rindfleisch 2nd Ed (1873) Ballieres et Fils. Paris, Translated by F Gross

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Details: Written by: Efrain A. Miranda, Ph.D.; Published: June 23, 2015; Hits: 8018

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UPDATED: The eponymic [Thebesian valve], or valve of the coronary sinus is a fold of endocardial tissue situated at the exit ostium of the coronary sinus. Named after Adam Christian Thebesius, the morphology of the valve presents with anatomical variations that go from total absence (see image here) to endocardial folds that cover up to 65% of the coronary sinus opening (see image in this article). The variations of the Thebesian valve include fenestrations, cribiriform valves, and the presence of pectineal cardiac muscle.

The Thebesian valve is important because it can be an obstruction to the passage of a catheter performing retrograde cardioplegia in electrophysiological studies, catheter ablation, and percutaneous mitral valve repair.

Thanks to Dr. Karuna Katti for allowing us the use of the image in this article. The image shows the interior of the right atrium with the inferior vena cava removed to demonstrate the Thebesian valve. In this case, the Thebesian valve covers >65% of the coronary sinus ostium. A catheter is being passed from the superior vena cava into the coronary sinus ostium.

The image shown a human heart with the right atrium and ventricle opened. VC, inferior vena cava; SVC, superior vena cava; TV, Thebesian valve.

Source:"The Thebesian Valve: Gatekeeper to the Coronary Sinus"Karuna Katti and Nikhil Prakash PatilClin Anat 25:379–385 (2012)

Thebesian valve

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