Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

Andreas Vesalius Bruxellensis (1514- 1564)

A Flemish anatomist and surgeon, Andreas Vesalius was born on December 31, 1514 in Brussels, Belgium. He is considered to be the father of the science of Anatomy. Up until his studies and publications human anatomy studies consisted only on the confirmation of the old doctrines of Galen of Pergamon (129AD - 200AD). Anatomy professors would read to the students from Galen's work and a demonstrator would point in a body to the area being described, if a body was used at all. The reasoning was that there was no need to dissect since all that was needed to know was already written in Galen's books. Vesalius, Fallopius, and others started the change by describing what they actually saw in a dissection as opposed to what was supposed to be there. 

Vesalius had a notorious career, both as an anatomist and as a surgeon. His revolutionary book "De Humani Corporis Fabrica: Libri Septem" was published in May 26, 1543. One of the most famous anatomical images is his plate 22 of the book, called sometimes "The Hamlet". You can see this image if you hover over Vesalius' only known portrait which accompanies this article. Sir William Osler said of this book "... it is the greatest book ever printed, from which modern medicine dates" 

After the original 1543 printing, the Fabrica was reprinted in 1555. It was re-reprinted and translated in many languages, although many of these printings were low-quality copies with no respect for copyright or authorship.

The story of the wood blocks with the carved images used for the original printing extends into the 20th century. In 1934 these original wood blocks were used to print 617 copies of the book "Iconaes Anatomica". This book is rare and no more can be printed because, sadly, during a 1943 WWII bombing raid over Munich all the wood blocks were burnt.

One interesting aspect of the book was the landscape panorama in some of his most famous woodcuts which was only "discovered" until 1903.

Vesalius was controversial in life and he still is in death. We know that he died on his way back from a pilgrimage to Jerusalem, but how he died, and exactly where he died is lost in controversy. We do know he was alive when he set foot on the port of Zakynthos in the island of the same name in Greece. He is said to have suddenly collapsed and die at the gates of the city, presumably as a consequence of scurvy. Records show that he was interred in the cemetery of the Church of Santa Maria delle Grazie, but the city and the church were destroyed by an earthquake and Vesalius' grave lost to history. Modern researchers are looking into finding the lost grave and have identified the location of the cemetery. This story has not ended yet.

For a detailed biography of Andreas Vesalius CLICK HERE.

Personal note: To commemorate Andrea Vesalius' 500th birthday in 2014, there were many scientific meetings throughout the world, one of them was the "Vesalius Continuum" anatomical meeting on the island of Zakynthos, Greece on September 4-8, 2014. This is the island where Vesalius died in 1564. I had the opportunity to attend and there are several articles in this website on the presence of Andreas Vesalius on Zakynthos island. During 2015 I also attended a symposium on "Vesalius and the Invention of the Modern Body" at the St. Louis University. At this symposium I had the honor of meeting of Drs. Garrison and Hast, authors of the "New Fabrica". Dr. Miranda


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Wilhelm His Jr.

This article is part of the series "A Moment in History" where we honor those who have contributed to the growth of medical knowledge in the areas of anatomy, medicine, surgery, and medical research.

Wilhelm His Jr.
Wilhelm His Jr.

Wilhelm His Jr. (1863-1934). Also known as Wilhelm His the Younger, was born in Switzerland in the city of Basel. His father was a well-known and famous anatomist by the same name who worked at the University of Basel. Wilhelm His Jr. studied in several universities, including Leipzig, Strasbourg, Bern, and Geneva. He received his medical degree from the University of Leipzig in 1889.

Although not an anatomist, his 1893 single and most brilliant contribution to the eventual understanding of the conduction system of the heart was the discovery and description of a muscular bundle that connected the atrial septum with the ventricular septum. Until that moment it was known that no muscles crossed from the atria to the ventricles, leading anatomists and physiologists to wonder how does the heart contract.  

In his article His states "after long search I have succeeded in finding a muscle bundle which unites the auricular and ventricular septal walls, and which, up to now, has escaped observation because of incomplete exposure, for it is visible in its entire extent only when the septa are cut exactly in their longitudinal direction".

What is interesting is that His not only found the bundle that today honors his name, but he included in that description the atrioventricular node, the actual structure that crosses the atrioventricular connective tissue barrier known as the "skeleton of the heart". The AV node was later to be clearly identified and researched by Sunao Tawara (1873 - 1952).

Dr. His continued his research on gout and joint diseases. He became a German citizen and joined the German army as a consulting physician. He retired in 1932 and died in 1934.

Although Wilhelm His Jr. did not discover or described the esophagogastric angle, in 1906 JD Cunningham started calling this angle the "Angle of His" in honor of Wilhelm His Jr. This eponym has stayed with us until today.

Sources:
1. "Wilhelm His Jr." JAMA. 1964;187(6):453-454
2. "His, Jr., W.: The Activity of the Embryonic Human Heart and Its Significance for the Understanding of the Heart Movement in the Adult" Arb Med Klin Leipzig, pp 14-49, 1893; Bast, TH,Gardner, WD trans: J Hist Med 4:289-318, 1949
3. "Wilhelm His, Jr. and the Bundle of His" Bast, TH, Gardner, WD J Hist Med All Sci; 1949; 4, (2) 170 -187
4. Firkin BG (1996) Dictionary of medical eponyms.London: Parthenon Publishing Group, 181
Original image
in the public domain, courtesy of the National Library of Medicine.