Martin W. Flack, CBE (1882

Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

You are welcome to submit questions and suggestions using our "Contact Us" form. The information on this blog follows the terms on our "Privacy and Security Statement" and cannot be construed as medical guidance or instructions for treatment.

A Moment in History

William S. Halsted, MD
(1852 – 1922)

American anatomist, teacher, and surgeon, William Stewart Halsted was born in New York City, USA to a wealthy family of English origin. His father was involved in charitable work and Governor and trustee to a city hospital. Not a brilliant student initially, Halsted took an undergraduate in Liberal Arts in Yale, CT., after which he entered the Medical College of Physicians at the Columbia College, where he excelled.

As a second-year medical student Halsted applied and obtained a position in surgery at a local hospital. In here he learned about Lister’s antiseptic technique and became an adamant proponent of it to reduce infection. In 1877 Halsted obtained his MD. After a short time as House Physician at the New York Hospital, Halsted traveled to Europe to further his education studying for two years at the Universities of Vienna, Leipzig, and W?rzburg.

Besides being at the forefront of surgical and antiseptic techniques (introducing the use of rubber gloves in surgery), Halsted was extremely concerned with the way medical students were taught in the US. He pioneered bedside clinical round discussions with the medical students after two years of basic sciences studies. Halsted developed the idea of a patient chart; he also developed the residency program for medical students in use today.

Halsted is probably the most influential researcher and surgeon at the turn of the century. He dedicated time to the study of intestinal anastomoses and the use of silk as a suture material. His experimental work in 1887 proved that the inclusion of the submucosa layer in an anastomosis was mandatory, as well that a single layered anastomosis was enough to attain closure. Perhaps Halsted’s most important contribution was the application and use of the scientific method to surgical questions. Halsted’s principles, also known as "Halsted's Rules of Surgery", set the standards used today in surgical suturing and surgical stapling.

He also pioneered the development and surgical techniques for radical mastectomy as a treatment for breast cancer.

As a side effect of this studied in anesthesia and the use of cocaine for anesthesia, Halsted became addicted to this substance, a problem that followed him through the years. Without impairing his capacity as a researcher and a surgeon, Halsted eventually recovered. He died in Baltimore in 1922 as a complication to surgery.

Sources:
1. Dubay, A. D., & Franz, G. M. (2003). Acute Wound Healing: The Biology of Acute Wound Failure. Surg Clin NA, 83, 463-481.
2. Halsted, W. S. (1887). Circular Suture of the Intestine - An Experimental Study. Am J Med Sci, 436-461.
3. “William Stewart Halsted: his life and contributions to surgery” Osborne, P. Lancet Oncol 2007; 8: 256–65
4. “William Stewart Halsted: Surgical pioneer” Burress, P Endoc Today (2010), 8: (2) 22
5. “William Stewart Halsted (1852–1922) Neurological stamp” Haas, LF J Neurol Neurosurg Psych 2000;69:641
Original image courtesy of "Images from the History of Medicine" at www.nih.gov

"Clinical Anatomy Associates, Inc., and the contributors of "Medical Terminology Daily" wish to thank all individuals who donate their bodies and tissues for the advancement of education and research”.

Click here for more information

Details: Published: January 15, 2026

This article is part of the series "A Moment in History" where we honor those who have contributed to the growth of medical knowledge in the areas of anatomy, medicine, surgery, and medical research.

Martin W. Flack, CBE
(1882 - 1931)

Martin William Flack, CBE (1882–1931), English physician and cardiovascular physiologist.

Born in 1882, in Borden, Kent, England. Flack studied Medicine and Surgery at Oxford University, graduating in 1908. While still a medical student at the London Hospital, Flack began his most important research under Arthur Keith’s guidance. In 1906 while examining histological glass slides of the heart of a mole, Flack identified a distinct cluster of specialized cardiac muscle cells at the junction of the superior vena cava and the right atrium. Working with Keith they realized that this was the source of the heartbeat. They termed this structure the “sino-auricular node”, known today as the sinoatrial node, and published their description in 1907, completing the anatomical mapping of the heart’s conduction system following earlier work on the atrioventricular node by Sunao Tawara.

Following this discovery, Flack continued in academia as demonstrator of physiology (1905–1911) and later as lecturer (1911–1914) at the London Hospital. He coauthored “A Textbook of Physiology” in 1919 and conducted research on the physiological responses of the sinoatrial node to temperature, mechanical stimulation, and pharmacological agents in the early 1910s, demonstrating its functional characteristics.

During World War I, Flack served on the Medical Research Council and contributed to studies concerning cardiorespiratory physiology. In 1919, he was appointed Director of Medical Research for the Royal Air Force where he conducted research on the physiological performance of pilots at high altitudes and on methods to assess pilot fitness, including cardiac and respiratory functions. His contributions to medical research and service were recognized with appointment as a Commander of the Order of the British Empire (CBE)

Sources:
1. Mohr PD. Illustrations of the heart by Arthur Keith: His work with James Mackenzie on the pathophysiology of the heart 1903–1908. J Med Biogr. 2021;30(3):193–201
2. Silverman ME, Hollman A. Discovery of the sinus node by Keith and Flack: on the centennial of their 1907 publication. Heart. 2007;93(10):1184–1187.
3. Keith A, Flack M. The Form and Nature of the Muscular Connections between the Primary Divisions of the Vertebrate Heart. J Anat Physiol. 1907 Apr;41(Pt 3):172-89. PMID: 17232727; PMCID: PMC1289112.
4. Keith A, Flack M. The form and nature of the muscular connections between the primary divisions of the vertebrate heart. J Anat Physiol 1907;41: 172–189
5. Dawadi, P; Khadka, S. Research and Medical Students: Some Notable Contributions Made in History. JNMA J Nepal Med Assoc. 2021 Jan 31;59(233):94–97

Images published in this article under SAGES permission on Creative Commons Attribution 4.0 License Other images Wellcome Collection Gallerypermission on Creative Commons Attribution 4.0 License

Martin W. Flack, CBE (1882–1931)

Recent