Medical Terminology Daily - Est. 2012

Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

William S. Halsted, MD

William S. Halsted, MD
(1852 – 1922)

American anatomist, teacher, and surgeon, William Stewart Halsted was born in New York City, USA to a wealthy family of English origin. His father was involved in charitable work and Governor and trustee to a city hospital. Not a brilliant student initially, Halsted took an undergraduate in Liberal Arts in Yale, CT., after which he entered the Medical College of Physicians at the Columbia College, where he excelled.

As a second-year medical student Halsted applied and obtained a position in surgery at a local hospital. In here he learned about Lister’s antiseptic technique and became an adamant proponent of it to reduce infection. In 1877 Halsted obtained his MD. After a short time as House Physician at the New York Hospital, Halsted traveled to Europe to further his education studying for two years at the Universities of Vienna, Leipzig, and W?rzburg.

Besides being at the forefront of surgical and antiseptic techniques (introducing the use of rubber gloves in surgery), Halsted was extremely concerned with the way medical students were taught in the US. He pioneered bedside clinical round discussions with the medical students after two years of basic sciences studies. Halsted developed the idea of a patient chart; he also developed the residency program for medical students in use today.

Halsted is probably the most influential researcher and surgeon at the turn of the century. He dedicated time to the study of intestinal anastomoses and the use of silk as a suture material. His experimental work in 1887 proved that the inclusion of the submucosa layer in an anastomosis was mandatory, as well that a single layered anastomosis was enough to attain closure. Perhaps Halsted’s most important contribution was the application and use of the scientific method to surgical questions. Halsted’s principles, also known as  "Halsted's Rules of Surgery", set the standards used today in surgical suturing and surgical stapling.

He also pioneered the development and surgical techniques for radical mastectomy as a treatment for breast cancer.

As a side effect of this studied in anesthesia and the use of cocaine for anesthesia, Halsted became addicted to this substance, a problem that followed him through the years. Without impairing his capacity as a researcher and a surgeon, Halsted eventually recovered. He died in Baltimore in 1922 as a complication to surgery.

Sources:
1. Dubay, A. D., & Franz, G. M. (2003). Acute Wound Healing: The Biology of Acute Wound Failure. Surg Clin NA, 83, 463-481.
2. Halsted, W. S. (1887). Circular Suture of the Intestine - An Experimental Study. Am J Med Sci, 436-461.
3. “William Stewart Halsted: his life and contributions to surgery” Osborne, P. Lancet Oncol 2007; 8: 256–65
4. “William Stewart Halsted: Surgical pioneer” Burress, P Endoc Today (2010), 8: (2) 22
5. “William Stewart Halsted (1852–1922) Neurological stamp” Haas, LF J Neurol Neurosurg Psych 2000;69:641
Original image courtesy of "Images from the History of Medicine" at  www.nih.gov


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Human Nervous system , the CNS and PNS
Human Nervous System

The medical term "ganglion" derives from the Greek γάγγλιο (gánglio) and means "a knot". It was initially used by Hippocrates of Cos (460 BC - 370 BC) to denote a small mass (tumor) under the skin. The term is still used in medicine to name small synovial cysts found near joint or around small tendons. The term was later used by Galen of Pergamon (129 AD - 200 AD) to name small nervous masses. The common use for the term in tendons and nerves is that the Greek made no distinction between these structures calling them [νευρών] (nevrón) meaning both tendon or sinew and nerve. The plural form for ganglion is "ganglia".

Today, the term "ganglion" is mostly used to denote a an encapsulated aggregation of neuronal cell bodies in the peripheral nervous system that serves as a relay, integration, or sensory transduction site. A ganglion may be part of simple and complex reflex circuits. A ganglion has an external capsule formed by connective tissue, neuronal bodies, and supportive neuroglial cells.

This term should not be used to refer to structures found in the central nervous system (CNS). An aggregation of neuronal bodies in the CNS is called a "nucleus", the plural form is "nuclei".

When intercommunicated, ganglia can form complex networks (plexi) inside the muscular layers of organs that have rhythmicity, such as the enteric and cardiac ganglionated plexi. These neuronal networks function as autonomic relays and integration sites, reducing the workload of the CNS.

Interestingly, ganglia can be found in small animals that lack a vertebrate-type CNS, illustrating their function in complex reflexes. Some examples are:

  • Echinodermata (sea stars, brittle stars/ophiuroids)
  • Cnidaria (jellyfish, sea anemones)
  • Flatworms (although it does have a cephalic ganglion that some contend is a "brain"

Sources:
1. Skinner, "The Origin of Medical Terms" 1970. William and Wilkins
2. Standring S, ed. Gray’s Anatomy: The Anatomical Basis of Clinical Practice. 42nd ed. Elsevier; 2021.
3. Anderson, Douglas M "Dorland's Illustrated Medical Dictionary"; ISBN: 0721655777 USA: W.B. Saunders, 1994.
4. Ross, Michael H, et al. "Histology: A Text and Atlas"; ISBN: 0683073699 Baltimore: Williams & Wilkins, 1995
5. Haines, Duane E. "Neuroanatomy: An Atlas of Structures, Sections and Systems"; ISBN: 9780781746779 Philadelphia: Lippincott, Williams & Wilkins, 2004.
6. Drake RL, Vogl W, Mitchell AWM.
Gray’s Anatomy for Students. 4th ed. Elsevier; 2020.