Ductus arteriosus

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A Moment in History

Georg Eduard Von Rindfleisch
(1836 – 1908)

German pathologist and histologist of Bavarian nobility ancestry. Rindfleisch studied medicine in Würzburg, Berlin, and Heidelberg, earning his MD in 1859 with the thesis “De Vasorum Genesi” (on the generation of vessels) under the tutelage of Rudolf Virchow (1821 - 1902). He then continued as a assistant to Virchow in a newly founded institute in Berlin. He then moved to Breslau in 1861 as an assistant to Rudolf Heidenhain (1834–1897), becoming a professor of pathological anatomy. In 1865 he became full professor in Bonn and in 1874 in Würzburg, where a new pathological institute was built according to his design (completed in 1878), where he worked until his retirement in 1906.

He was the first to describe the inflammatory background of multiple sclerosis in 1863, when he noted that demyelinated lesions have in their center small vessels that are surrounded by a leukocyte inflammatory infiltrate.

After extensive investigations, he suspected an infectious origin of tuberculosis - even before Robert Koch's detection of the tuberculosis bacillus in 1892. Rindfleisch 's special achievement is the description of the morphologically conspicuous macrophages in typhoid inflammation. His distinction between myocardial infarction and myocarditis in 1890 is also of lasting importance.

Associated eponyms

"Rindfleisch's folds": Usually a single semilunar fold of the serous surface of the pericardium around the origin of the aorta. Also known as the plica semilunaris aortæ.

"Rindfleisch's cells": Historical (and obsolete) name for eosinophilic leukocytes.

Personal note: G. Rindfleisch’s book “Traité D' Histologie Pathologique” 2nd edition (1873) is now part of my library. This book was translated from German to French by Dr. Frédéric Gross (1844-1927) , Associate Professor of the Medicine Faculty in Nancy, France. The book is dedicated to Dr. Theodore Billroth (1829-1894), an important surgeon whose pioneering work on subtotal gastrectomies paved the way for today’s robotic bariatric surgery. Dr. Miranda.

Sources:
1. "Stedmans Medical Eponyms" Forbis, P.; Bartolucci, SL; 1998 Williams and Wilkins
2. "Rindfleisch, Georg Eduard von (bayerischer Adel?)" Deutsche Biographie
3. "The pathology of multiple sclerosis and its evolution" Lassmann H. (1999) Philos Trans R Soc Lond B Biol Sci. 354 (1390): 1635–40.
4. “Traité D' Histologie Pathologique” G.E.
Rindfleisch 2nd Ed (1873) Ballieres et Fils. Paris, Translated by F Gross

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Details: Written by: Efrain A. Miranda, Ph.D.; Published: February 02, 2015; Hits: 4486

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The term [ductus arteriosus] is Latin and means “arterial duct”. The ductus arteriosus a component of fetal circulation and is a communication between the left pulmonary artery, close to its origin from the pulmonary trunk, and the inferior aspect of the aortic arch. This structure is also called the “duct of Botallus”.

The fetus oxygenates its blood using the placenta; therefore it does not need to use its lungs. The fetal blood is diverted from the right atrium to the left atrium through the foramen ovale. Still, some blood will pass from the right atrium to the right ventricle and then through the pulmonary valve into the pulmonary trunk. The ductus arteriosus will divert most of this blood, so that instead of going into the lungs, the blood will go into the aortic arch and then to the systemic circulation.

Once the baby is born, this right to left shunt is not needed and the foramen ovale will close immediately after birth, while the ductus arteriosus will slowly reduce its diameter to be completely closed in a few days. If this closure does not happen, the condition will be referred to as a “patent ductus arteriosus” or PDA.

Once the ductus arteriosus is close it is referred to as the “ligamentum arteriosus” or the “ligament of Botallus”, named after Leonardo Botallus (c.1530-????)

Sources:
1. "Gray's Anatomy"38th British Ed. Churchill Livingstone 1995
2. "Tratado de Anatomia Humana" Testut et Latarjet 8 Ed. 1931 Salvat Editores, Spain
Image by BrownCow. [Public domain], from Wikimedia Commons

Ductus arteriosus

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