Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

Andreas Vesalius Bruxellensis (1514- 1564)

A Flemish anatomist and surgeon, Andreas Vesalius was born on December 31, 1514 in Brussels, Belgium. He is considered to be the father of the science of Anatomy. Up until his studies and publications human anatomy studies consisted only on the confirmation of the old doctrines of Galen of Pergamon (129AD - 200AD). Anatomy professors would read to the students from Galen's work and a demonstrator would point in a body to the area being described, if a body was used at all. The reasoning was that there was no need to dissect since all that was needed to know was already written in Galen's books. Vesalius, Fallopius, and others started the change by describing what they actually saw in a dissection as opposed to what was supposed to be there. 

Vesalius had a notorious career, both as an anatomist and as a surgeon. His revolutionary book "De Humani Corporis Fabrica: Libri Septem" was published in May 26, 1543. One of the most famous anatomical images is his plate 22 of the book, called sometimes "The Hamlet". You can see this image if you hover over Vesalius' only known portrait which accompanies this article. Sir William Osler said of this book "... it is the greatest book ever printed, from which modern medicine dates" 

After the original 1543 printing, the Fabrica was reprinted in 1555. It was re-reprinted and translated in many languages, although many of these printings were low-quality copies with no respect for copyright or authorship.

The story of the wood blocks with the carved images used for the original printing extends into the 20th century. In 1934 these original wood blocks were used to print 617 copies of the book "Iconaes Anatomica". This book is rare and no more can be printed because, sadly, during a 1943 WWII bombing raid over Munich all the wood blocks were burnt.

One interesting aspect of the book was the landscape panorama in some of his most famous woodcuts which was only "discovered" until 1903.

Vesalius was controversial in life and he still is in death. We know that he died on his way back from a pilgrimage to Jerusalem, but how he died, and exactly where he died is lost in controversy. We do know he was alive when he set foot on the port of Zakynthos in the island of the same name in Greece. He is said to have suddenly collapsed and die at the gates of the city, presumably as a consequence of scurvy. Records show that he was interred in the cemetery of the Church of Santa Maria delle Grazie, but the city and the church were destroyed by an earthquake and Vesalius' grave lost to history. Modern researchers are looking into finding the lost grave and have identified the location of the cemetery. This story has not ended yet.

For a detailed biography of Andreas Vesalius CLICK HERE.

Personal note: To commemorate Andrea Vesalius' 500th birthday in 2014, there were many scientific meetings throughout the world, one of them was the "Vesalius Continuum" anatomical meeting on the island of Zakynthos, Greece on September 4-8, 2014. This is the island where Vesalius died in 1564. I had the opportunity to attend and there are several articles in this website on the presence of Andreas Vesalius on Zakynthos island. During 2015 I also attended a symposium on "Vesalius and the Invention of the Modern Body" at the St. Louis University. At this symposium I had the honor of meeting of Drs. Garrison and Hast, authors of the "New Fabrica". Dr. Miranda


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Ruggero Oddi

This article is part of the series "A Moment in History" where we honor those who have contributed to the growth of medical knowledge in the areas of anatomy, medicine, surgery, and medical research.

Ruggero Oddi
Ruggero Oddi

Ruggero Oddi  (1864-1913). Anatomist and physician, his complete name was Ruggero Ferdinando Antonio Giuseppe Vincenzo Oddi Pampaglini, born on July 20, 1814 in the city of Perugia, Italy.  He studied medicine in the University of Perugia, where he had a keen interest in anatomy and physiology, graduation with a medical degree in 1889. In 1887, as a fourth year medical student Oddi published a paper that would make his name eponymically tied to the sphincter found around the hepatopancreatic ampulla; what today is known as the "sphincter of Oddi". His paper was entitled "Di una Speciale Disposizione a Sfintere allo Sbocco del Coledoco" (On a Special Sphincteric Arrangement at the Outlet of the Common Bile Duct).

Although the circular muscle of the sphincter of Oddi had already been described by Glisson in 1681, Oddi was the one who did a complete anatomical and physiological study of this structure uncovering the fact that it was indeed a sphincter. He continued his studies on the hepatobiliary sphincter until 1894, when he moved to Congo and later back to Belgium. 

Because of his inclination towards metaphysical studies, Oddi started experimenting with drugs on himself and became addicted.

His later life was surrounded by scandal and controversy, because of drug abuse and fiscal mismanagement of University funds. Oddi died in poverty in 1913 and his site of burial is unknown.

Sources:
1. "Ruggero Ferdinando Antonio Guiseppe Vincenzo Oddi" Lukas, M, et al. World J Surg (2007) 31:2260–2265
2. "Ruggero Oddi; To commemorate the centennial of his original article--"Di unaspeciale disposizione a sfintere allo sbocco del coledoco" Ono, K; Hada, R. Jap J Surg, VOL. 18, No. 4 pp. 373-375, 1988
3. "Ruggero Oddi: 120 years after the description of the eponymous sphincter: A story to be remembered" Capodicasa, E. J Gastroent Hepat 23 (2008) 1200–1203
4. "Oddi: The Paradox of the Man and the Sphincter" Modlin, IM; Ahlman, H. Arch Surg 129 (1994) May 550-557
Original image in the public domain, courtesy of the  National Library of Medicine.