Ventral

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A Moment in History

Georg Eduard Von Rindfleisch
(1836 – 1908)

German pathologist and histologist of Bavarian nobility ancestry. Rindfleisch studied medicine in Würzburg, Berlin, and Heidelberg, earning his MD in 1859 with the thesis “De Vasorum Genesi” (on the generation of vessels) under the tutelage of Rudolf Virchow (1821 - 1902). He then continued as a assistant to Virchow in a newly founded institute in Berlin. He then moved to Breslau in 1861 as an assistant to Rudolf Heidenhain (1834–1897), becoming a professor of pathological anatomy. In 1865 he became full professor in Bonn and in 1874 in Würzburg, where a new pathological institute was built according to his design (completed in 1878), where he worked until his retirement in 1906.

He was the first to describe the inflammatory background of multiple sclerosis in 1863, when he noted that demyelinated lesions have in their center small vessels that are surrounded by a leukocyte inflammatory infiltrate.

After extensive investigations, he suspected an infectious origin of tuberculosis - even before Robert Koch's detection of the tuberculosis bacillus in 1892. Rindfleisch 's special achievement is the description of the morphologically conspicuous macrophages in typhoid inflammation. His distinction between myocardial infarction and myocarditis in 1890 is also of lasting importance.

Associated eponyms

"Rindfleisch's folds": Usually a single semilunar fold of the serous surface of the pericardium around the origin of the aorta. Also known as the plica semilunaris aortæ.

"Rindfleisch's cells": Historical (and obsolete) name for eosinophilic leukocytes.

Personal note: G. Rindfleisch’s book “Traité D' Histologie Pathologique” 2nd edition (1873) is now part of my library. This book was translated from German to French by Dr. Frédéric Gross (1844-1927) , Associate Professor of the Medicine Faculty in Nancy, France. The book is dedicated to Dr. Theodore Billroth (1829-1894), an important surgeon whose pioneering work on subtotal gastrectomies paved the way for today’s robotic bariatric surgery. Dr. Miranda.

Sources:
1. "Stedmans Medical Eponyms" Forbis, P.; Bartolucci, SL; 1998 Williams and Wilkins
2. "Rindfleisch, Georg Eduard von (bayerischer Adel?)" Deutsche Biographie
3. "The pathology of multiple sclerosis and its evolution" Lassmann H. (1999) Philos Trans R Soc Lond B Biol Sci. 354 (1390): 1635–40.
4. “Traité D' Histologie Pathologique” G.E.
Rindfleisch 2nd Ed (1873) Ballieres et Fils. Paris, Translated by F Gross

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Details: Written by: Efrain A. Miranda, Ph.D.; Published: December 09, 2023; Hits: 7108

Lateral view - Human embryo about
eight and a half weeks old

(UPDATED) The term [ventral] arises from the Latin word [venter] and the root term [ventr-] meaning "belly" or "sac". The adjective [ventral] means "towards the front" , or "towards the belly side of the body". The term ventral therefore means "abdomen".

Many use the term [ventral] synonymously with "anterior"; although this is technically correct, the proper term to use when referring to the patient in the anatomical position should be "anterior". In embryology, since the embryo is curved, most of the anterior aspect of the embryo looks towards the abdomen, ergo ventral.

A ventral hernia is any herniation that occurs in the anterior aspect of the abdomen, including Spigelian hernias, omphaloceles, etc.

Other terms that arise from the same root term are [ventricle], meaning "little belly", or "little sac", and [ventricular], meaning "pertaining to a ventricle".

Note: A comment from my friend Dr. Elizabeth Murray:

"My understanding of "anterior" means "in the direction of movement" for any given organism (and "posterior" means opposite the direction of movement for an organism). Thus, ventral does not ever change for any creature (vertebrate or even invertebrate), as it refers to a body part/surface. But when considering two-legged and four-legged (or finned) creatures, you see the differences: Ventral = anterior in us, but in a dog or fish ventral = inferior.

Ventral/dorsal refer to belly/back in any organism, and cranial/caudal refer to head-end and tail-end in any organism -- those four terms refer to body parts. However, anterior/posterior refer to the way an organism moves in space, and superior/inferior refer to an organism's relationship to the earth/pull of gravity."

An interesting side note: The word [ventriloquist] arises from the root term [-ventri-] from the Latin [venter] and the suffix [-loquist], from the Latin [loquos] and [locutus], meaning "to speak", or "someone who speaks". The term [ventriloquist] means then "someone who speaks from the abdomen (or stomach)". We now know that this is not so, but that is what most people think a ventriloquist does!

Sources:
1 "Tratado de Anatomia Humana" Testut et Latarjet 8 Ed. 1931 Salvat Editores, Spain
2. "Anatomy of the Human Body" Henry Gray 1918. Philadelphia: Lea & Febiger
Image modified by CAA, Inc. Original image by Henry Vandyke Carter, MD., courtesy of bartleby.com

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