Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

Andreas Vesalius Bruxellensis (1514- 1564)

A Flemish anatomist and surgeon, Andreas Vesalius was born on December 31, 1514 in Brussels, Belgium. He is considered to be the father of the science of Anatomy. Up until his studies and publications human anatomy studies consisted only on the confirmation of the old doctrines of Galen of Pergamon (129AD - 200AD). Anatomy professors would read to the students from Galen's work and a demonstrator would point in a body to the area being described, if a body was used at all. The reasoning was that there was no need to dissect since all that was needed to know was already written in Galen's books. Vesalius, Fallopius, and others started the change by describing what they actually saw in a dissection as opposed to what was supposed to be there. 

Vesalius had a notorious career, both as an anatomist and as a surgeon. His revolutionary book "De Humani Corporis Fabrica: Libri Septem" was published in May 26, 1543. One of the most famous anatomical images is his plate 22 of the book, called sometimes "The Hamlet". You can see this image if you hover over Vesalius' only known portrait which accompanies this article. Sir William Osler said of this book "... it is the greatest book ever printed, from which modern medicine dates" 

After the original 1543 printing, the Fabrica was reprinted in 1555. It was re-reprinted and translated in many languages, although many of these printings were low-quality copies with no respect for copyright or authorship.

The story of the wood blocks with the carved images used for the original printing extends into the 20th century. In 1934 these original wood blocks were used to print 617 copies of the book "Iconaes Anatomica". This book is rare and no more can be printed because, sadly, during a 1943 WWII bombing raid over Munich all the wood blocks were burnt.

One interesting aspect of the book was the landscape panorama in some of his most famous woodcuts which was only "discovered" until 1903.

Vesalius was controversial in life and he still is in death. We know that he died on his way back from a pilgrimage to Jerusalem, but how he died, and exactly where he died is lost in controversy. We do know he was alive when he set foot on the port of Zakynthos in the island of the same name in Greece. He is said to have suddenly collapsed and die at the gates of the city, presumably as a consequence of scurvy. Records show that he was interred in the cemetery of the Church of Santa Maria delle Grazie, but the city and the church were destroyed by an earthquake and Vesalius' grave lost to history. Modern researchers are looking into finding the lost grave and have identified the location of the cemetery. This story has not ended yet.

For a detailed biography of Andreas Vesalius CLICK HERE.

Personal note: To commemorate Andrea Vesalius' 500th birthday in 2014, there were many scientific meetings throughout the world, one of them was the "Vesalius Continuum" anatomical meeting on the island of Zakynthos, Greece on September 4-8, 2014. This is the island where Vesalius died in 1564. I had the opportunity to attend and there are several articles in this website on the presence of Andreas Vesalius on Zakynthos island. During 2015 I also attended a symposium on "Vesalius and the Invention of the Modern Body" at the St. Louis University. At this symposium I had the honor of meeting of Drs. Garrison and Hast, authors of the "New Fabrica". Dr. Miranda


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Empedocles of Agrigentum

This article is part of the series "A Moment in History" where we honor those who have contributed to the growth of medical knowledge in the areas of anatomy, medicine, surgery, and medical research.

Empedocles of Agrigentum
Empedocles of Agrigentum

Empedocles of Agrigentum (ca. 495–430 BC). Greek philosopher, poet, physician, physiologist, politician, Empedocles was born in the city of Agrigentum, a Greek colony in Sicily.

Empedocles presented himself as an immortal god. Versed in magic and incantations, he was seen as a healer by people that followed him.

A philosopher, Empedocles developed the theory that nature consists of the combination of four “elements”— earth, water, air, and fire —with each of these elements being a combination of two qualities:  water is wet and cold, air is dry and cold, fire is dry and hot, and earth is wet and hot. Empedocles went further to explain that the combination of these elements is based on the balance of love and hate. The balance of the elements represented balance in life.

Further development of this theory by observation of the human body, led to the “Humor theory” or “bodily fluids” theory based on four fluids whose imbalance led to disease. The four humors were “blood” or sanguineous, which belongs to the air element, “phlegm”, which belongs to water, “yellow bile”, which corresponds to fire, and “black bile” or “melancholy” which corresponds to earth. This theory dominated human physiology and medicine until the 17th century.

Because the humor theory also explained moods and temperaments, Empedocles’ influence is still seen in our language as we refer to people and personalities as “phlegmatic”, “sanguine”, “bilious”, and “melancholy”.

Empedocles’ death is the stuff of legend. To maintain his image as a god, he threw himself into the Etna volcano to disappear. This was foiled as it is said that the volcano spew one of his golden sandals. Others said that he made a “divinity” party and after dinner when everyone was asleep he disappeared, making everyone believe he had risen to heaven. Fact is, we do not know.

Sources
1. “Mythical Conceptions of the Problem of the Unity of Culture” Tagliacozzo, G. Am Behav Scient Apr 1963; 6-8
2. “The Nature and Formation of Teeth According to Spanish Authors from the 16th to the 18th Centuries” Romero-Maroto, M. J Dent Res (2008) 87(2):103-106
3. “The evolution of Modern Medicine” Osler, W. 2nd Ed. Yale University Press 1922
4. “Empedocles” N Brit Rev Vol LXV (1866) 420-440