Carl Wernicke

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A Moment in History

Georg Eduard Von Rindfleisch
(1836 – 1908)

German pathologist and histologist of Bavarian nobility ancestry. Rindfleisch studied medicine in Würzburg, Berlin, and Heidelberg, earning his MD in 1859 with the thesis “De Vasorum Genesi” (on the generation of vessels) under the tutelage of Rudolf Virchow (1821 - 1902). He then continued as a assistant to Virchow in a newly founded institute in Berlin. He then moved to Breslau in 1861 as an assistant to Rudolf Heidenhain (1834–1897), becoming a professor of pathological anatomy. In 1865 he became full professor in Bonn and in 1874 in Würzburg, where a new pathological institute was built according to his design (completed in 1878), where he worked until his retirement in 1906.

He was the first to describe the inflammatory background of multiple sclerosis in 1863, when he noted that demyelinated lesions have in their center small vessels that are surrounded by a leukocyte inflammatory infiltrate.

After extensive investigations, he suspected an infectious origin of tuberculosis - even before Robert Koch's detection of the tuberculosis bacillus in 1892. Rindfleisch 's special achievement is the description of the morphologically conspicuous macrophages in typhoid inflammation. His distinction between myocardial infarction and myocarditis in 1890 is also of lasting importance.

Associated eponyms

"Rindfleisch's folds": Usually a single semilunar fold of the serous surface of the pericardium around the origin of the aorta. Also known as the plica semilunaris aortæ.

"Rindfleisch's cells": Historical (and obsolete) name for eosinophilic leukocytes.

Personal note: G. Rindfleisch’s book “Traité D' Histologie Pathologique” 2nd edition (1873) is now part of my library. This book was translated from German to French by Dr. Frédéric Gross (1844-1927) , Associate Professor of the Medicine Faculty in Nancy, France. The book is dedicated to Dr. Theodore Billroth (1829-1894), an important surgeon whose pioneering work on subtotal gastrectomies paved the way for today’s robotic bariatric surgery. Dr. Miranda.

Sources:
1. "Stedmans Medical Eponyms" Forbis, P.; Bartolucci, SL; 1998 Williams and Wilkins
2. "Rindfleisch, Georg Eduard von (bayerischer Adel?)" Deutsche Biographie
3. "The pathology of multiple sclerosis and its evolution" Lassmann H. (1999) Philos Trans R Soc Lond B Biol Sci. 354 (1390): 1635–40.
4. “Traité D' Histologie Pathologique” G.E.
Rindfleisch 2nd Ed (1873) Ballieres et Fils. Paris, Translated by F Gross

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Carl Wernicke

Published: Monday, May 13, 2013 07:00 | Written by: Efrain A. Miranda, Ph.D. | Hits: 7137

This article is part of the series "A Moment in History" where we honor those who have contributed to the growth of medical knowledge in the areas of anatomy, medicine, surgery, and medical research.

Carl Wernicke

Carl Wernicke (1848-1905). German psychiatrist, neurologist, and neurosurgeon, Carl Wernicke was born in 1848 in the town of Tarnowitz, in what was then Prussia. He studied medicine in Breslau, Poland. In 1817 he became an assistant psychiatrist at a Breslau hospital. Fascinated with the discoveries and publications of Paul Broca on localized brain damage and aphasia, Wernicke left his post for a time to work with Theodor Meynert in Vienna. At that time Meynert was considered an authority in neuropsychiatry. In 1874, soon after his return to Breslau, Wernicke published his ideas and findings in aphasia in a revolutionary publication "The Aphasia Symptom Complex". Wernicke was only 26.

At the time, the general outlook on brain activity was that the brain worked in localized areas. Carl Wernicke's ideas were that although this was true, the functionality of the brain resided in the connections between the different areas of the brain. His ideas were right. Wernicke described what later would be known as "sensory aphasia" or the eponymic "Wernicke's aphasia".

Wernicke was a pioneer in the surgical treatment of hydrocephalus, as well as the surgical treatment of brain abscesses. He published several books, including a brain atlas. Carl Wernicke died as the consequence of a bicycle accident in 1905.

Sources:
1. "Pioneers in Neurology: Carl Wernicke (1848–1905)" Pillmann, F. J Neurol (2003) 250 : 1390–1391
2. "The scientific history of hydrocephalus and its treatment" Aschoff, A.; Ashemi, P.; Kunze, S.Neurosurg Rev (1999) 22:67–93
3. "Aphasia" Marshall,RS; Lazar, RM;PhD, Mohr,JP. Medical Update for Psychiatrists. Elsevier (1998)3;5:132–138