Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

Georg Eduard Von Rindfleisch

Georg Eduard Von Rindfleisch
(1836 – 1908)

German pathologist and histologist of Bavarian nobility ancestry. Rindfleisch studied medicine in Würzburg, Berlin, and Heidelberg, earning his MD in 1859 with the thesis “De Vasorum Genesi” (on the generation of vessels) under the tutelage of Rudolf Virchow (1821 - 1902). He then continued as a assistant to Virchow in a newly founded institute in Berlin. He then moved to Breslau in 1861 as an assistant to Rudolf Heidenhain (1834–1897), becoming a professor of pathological anatomy. In 1865 he became full professor in Bonn and in 1874 in Würzburg, where a new pathological institute was built according to his design (completed in 1878), where he worked until his retirement in 1906.

He was the first to describe the inflammatory background of multiple sclerosis in 1863, when he noted that demyelinated lesions have in their center small vessels that are surrounded by a leukocyte inflammatory infiltrate.

After extensive investigations, he suspected an infectious origin of tuberculosis - even before Robert Koch's detection of the tuberculosis bacillus in 1892. Rindfleisch 's special achievement is the description of the morphologically conspicuous macrophages in typhoid inflammation. His distinction between myocardial infarction and myocarditis in 1890 is also of lasting importance.

Associated eponyms

"Rindfleisch's folds": Usually a single semilunar fold of the serous surface of the pericardium around the origin of the aorta. Also known as the plica semilunaris aortæ.

"Rindfleisch's cells": Historical (and obsolete) name for eosinophilic leukocytes.

Personal note: G. Rindfleisch’s book “Traité D' Histologie Pathologique” 2nd edition (1873) is now part of my library. This book was translated from German to French by Dr. Frédéric Gross (1844-1927) , Associate Professor of the Medicine Faculty in Nancy, France. The book is dedicated to Dr. Theodore Billroth (1829-1894), an important surgeon whose pioneering work on subtotal gastrectomies paved the way for today’s robotic bariatric surgery. Dr. Miranda.

Sources:
1. "Stedmans Medical Eponyms" Forbis, P.; Bartolucci, SL; 1998 Williams and Wilkins
2. "Rindfleisch, Georg Eduard von (bayerischer Adel?)" Deutsche Biographie
3. "The pathology of multiple sclerosis and its evolution" Lassmann H. (1999)  Philos Trans R Soc Lond B Biol Sci. 354 (1390): 1635–40.
4. “Traité D' Histologie Pathologique” G.E.
Rindfleisch 2nd Ed (1873) Ballieres et Fils. Paris, Translated by F Gross


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Another Vesaliana great find is now in my office

1543 Fabrica Title Page
1543 Fabrica Title Page

One of the most collectible books in medical sciences and specifically in human anatomy is “De Humani Corporis Fabrica; Libri Septem” (Seven books on the structure of the Human Body) published in 1543 by Andreas Vesalius. This book is known as the “Fabrica” among Vesaliana enthusiasts.

The story of the Fabrica is complicated and the books, research papers, paintings, statues, medals, etc. on Vesalius and the Fabrica number in the thousands.

The first edition of the Fabrica was published in 1543, it was well received and was followed by the second edition in 1555. Vesalius died in 1564 and no further editions of the Fabrica were published. There are several translations in different languages, the latest is the “New Fabrica” published in 2013. This book included annotations by Vesalius himself found in a 1555 Fabrica. This particular “Annotated Fabrica” has a history worth reading and is one of the most expensive books ever sold at an auction in February 2024 for 2.23 million US dollars.

Part of book collectibles are single pages cut off a book. This method was quite common among antiquarians in the late 1800’s and early 1900’s. As a book collector, I think it is not a good idea to destroy a great book in the quest to obtain more money selling it as individual pages.

Be that as it may, in early 2023 I was notified by my good friend Dr. Randall Wolf, one of the contributors of Clinical Anatomy Associates, of an auction by Potter and Potter where two loose pages of the 1543 Fabrica would be placed on the auction block. With his help and lots of luck, I was able to secure item 298, which was a single page of the Fabrica, page 187, one of the “muscle men”, which depicts the “Liber II, Sexta Musculorum Tabula” (Book 2, Sixth Muscle Image).

Potter and Potter Auctions June 2023Cover page of the June 2023 Potter&Potter Auction

Potterandpotter187 smItem 298 description

One of the problems that collectors face is to prove that a certain item is original, the second one is provenance (where does the item come from?).

The first question was answered in Belgium when Dr. Wolf and I visited Dr. Francis Van Glabbeek and his personal collection in June 2023 with occasion of the 2023 Vesalius Triennial Meeting in the city of Antwerp. We were able to compare in minute detail the original image and my single page, including the type of paper and the text on the opposite page. They were a perfect match, proving that this page was indeed taken of an original 1543 Fabrica.

Reviewing the 1543 Fabrica with Drs. Wolf and Van GlabbeekStudying page 187

Getting goosebumps...
Getting goosebumps...

Reviewing the 1543 Fabrica with Drs. Wolf and Van GlabbeekLooking at details...

Confirmed

Confirmed!! It is an original 1543 page!

The second question was answered by the auctioneer, as the page belonged to the library of Ronald K. Siegel, PH.D. (1943-2019), an American psychopharmacologist and associate research professor in the Department of Psychiatry and Behavioral Sciences at the University of California, Los Angeles (UCLA). Before Dr. Siegel, we do not know how or when he acquired this single leaf of the Fabrica.

The page was carefully framed by Becky Gebhart, owner of “Picture This” in Lebanon, OH, and is secured with museum-quality glass. It in now on the wall facing my desk. Here it is:

Page 187 of the 1534 FabricaPage 188, the verso of page 187 is not visible because of the frame. This page title is "Sextæ Musculorum tabulæ charactermum index" and lists the symbols on the image.

Fabrica page 188