Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

Georg Eduard Von Rindfleisch

Georg Eduard Von Rindfleisch
(1836 – 1908)

German pathologist and histologist of Bavarian nobility ancestry. Rindfleisch studied medicine in Würzburg, Berlin, and Heidelberg, earning his MD in 1859 with the thesis “De Vasorum Genesi” (on the generation of vessels) under the tutelage of Rudolf Virchow (1821 - 1902). He then continued as a assistant to Virchow in a newly founded institute in Berlin. He then moved to Breslau in 1861 as an assistant to Rudolf Heidenhain (1834–1897), becoming a professor of pathological anatomy. In 1865 he became full professor in Bonn and in 1874 in Würzburg, where a new pathological institute was built according to his design (completed in 1878), where he worked until his retirement in 1906.

He was the first to describe the inflammatory background of multiple sclerosis in 1863, when he noted that demyelinated lesions have in their center small vessels that are surrounded by a leukocyte inflammatory infiltrate.

After extensive investigations, he suspected an infectious origin of tuberculosis - even before Robert Koch's detection of the tuberculosis bacillus in 1892. Rindfleisch 's special achievement is the description of the morphologically conspicuous macrophages in typhoid inflammation. His distinction between myocardial infarction and myocarditis in 1890 is also of lasting importance.

Associated eponyms

"Rindfleisch's folds": Usually a single semilunar fold of the serous surface of the pericardium around the origin of the aorta. Also known as the plica semilunaris aortæ.

"Rindfleisch's cells": Historical (and obsolete) name for eosinophilic leukocytes.

Personal note: G. Rindfleisch’s book “Traité D' Histologie Pathologique” 2nd edition (1873) is now part of my library. This book was translated from German to French by Dr. Frédéric Gross (1844-1927) , Associate Professor of the Medicine Faculty in Nancy, France. The book is dedicated to Dr. Theodore Billroth (1829-1894), an important surgeon whose pioneering work on subtotal gastrectomies paved the way for today’s robotic bariatric surgery. Dr. Miranda.

Sources:
1. "Stedmans Medical Eponyms" Forbis, P.; Bartolucci, SL; 1998 Williams and Wilkins
2. "Rindfleisch, Georg Eduard von (bayerischer Adel?)" Deutsche Biographie
3. "The pathology of multiple sclerosis and its evolution" Lassmann H. (1999)  Philos Trans R Soc Lond B Biol Sci. 354 (1390): 1635–40.
4. “Traité D' Histologie Pathologique” G.E.
Rindfleisch 2nd Ed (1873) Ballieres et Fils. Paris, Translated by F Gross


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"Vesalius and the Invention of the Modern Body"

Vesalius and the Invention of the Modern Body
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Last week I attended this interdisciplinary symposium hosted by the Saint Louis University and Washington University. This three-day event was inspired by the landmark publication of Andrea Vesalius’s "De humani corporis fabrica, libri septem" (Basel, 1543 and 1555) and the new critical edition and translation of this work, the New Fabrica. Two of the keynote speakers were Daniel Garrison and  Malcolm Hast, authors of the new Fabrica by Karger Publishers. Besides them there were several internationally-renowned speakers, art exhibits, presentation of academic papers of leading research, a public anatomy demonstration, rare books workshops, and a publishers’ exhibit hall.

Because the Fabrica represented a collaborative project involving a scientist (Vesalius), a humanist (Johannes Oporinus, the printer), and an artist (Jan van Kalkar), the goal of the conference was to encourage a network of scholars working in disparate fields to explore the potential for future interdisciplinary research. This objective was clearly attained, as I was able to speak and share with rare books curators, university librarians, artists, anatomist, physicians, poets, historians, etc., all of them brought together by the shared admiration for Andreas Vesalius, his work, his publications, and his legacy.

There were many highlights in this symposium and I will try to cover some of them in a series of articles.  The first one was a presentation by Dr. Stephen N. Joffe, where he described the number of Vesalius' books still in existence in the US and estimates around the world. It was interesting to me that and estimated 600 first edition Fabricas were ever published, and that of those only a fraction exist today, most in university libraries!

Another highlight was the presentation by Pascale Pollier, a Belgian artist, of the Vesalius Continuum project, part of which are the Fabrica Vitae art exhibit that was available to the attendees and the public for the duration of the symposium. Another part of Vesalius Continuum was the meeting in Zakynthos, Greece in 2014. Pascale also presented the process of creation of a bust of Dr. Gunther Von Hagens, the inventor of the system of plastination.

Probably the most rewarding segments of this symposium were the question and answer sessions after each presentation.