Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

Georg Eduard Von Rindfleisch

Georg Eduard Von Rindfleisch
(1836 – 1908)

German pathologist and histologist of Bavarian nobility ancestry. Rindfleisch studied medicine in Würzburg, Berlin, and Heidelberg, earning his MD in 1859 with the thesis “De Vasorum Genesi” (on the generation of vessels) under the tutelage of Rudolf Virchow (1821 - 1902). He then continued as a assistant to Virchow in a newly founded institute in Berlin. He then moved to Breslau in 1861 as an assistant to Rudolf Heidenhain (1834–1897), becoming a professor of pathological anatomy. In 1865 he became full professor in Bonn and in 1874 in Würzburg, where a new pathological institute was built according to his design (completed in 1878), where he worked until his retirement in 1906.

He was the first to describe the inflammatory background of multiple sclerosis in 1863, when he noted that demyelinated lesions have in their center small vessels that are surrounded by a leukocyte inflammatory infiltrate.

After extensive investigations, he suspected an infectious origin of tuberculosis - even before Robert Koch's detection of the tuberculosis bacillus in 1892. Rindfleisch 's special achievement is the description of the morphologically conspicuous macrophages in typhoid inflammation. His distinction between myocardial infarction and myocarditis in 1890 is also of lasting importance.

Associated eponyms

"Rindfleisch's folds": Usually a single semilunar fold of the serous surface of the pericardium around the origin of the aorta. Also known as the plica semilunaris aortæ.

"Rindfleisch's cells": Historical (and obsolete) name for eosinophilic leukocytes.

Personal note: G. Rindfleisch’s book “Traité D' Histologie Pathologique” 2nd edition (1873) is now part of my library. This book was translated from German to French by Dr. Frédéric Gross (1844-1927) , Associate Professor of the Medicine Faculty in Nancy, France. The book is dedicated to Dr. Theodore Billroth (1829-1894), an important surgeon whose pioneering work on subtotal gastrectomies paved the way for today’s robotic bariatric surgery. Dr. Miranda.

Sources:
1. "Stedmans Medical Eponyms" Forbis, P.; Bartolucci, SL; 1998 Williams and Wilkins
2. "Rindfleisch, Georg Eduard von (bayerischer Adel?)" Deutsche Biographie
3. "The pathology of multiple sclerosis and its evolution" Lassmann H. (1999)  Philos Trans R Soc Lond B Biol Sci. 354 (1390): 1635–40.
4. “Traité D' Histologie Pathologique” G.E.
Rindfleisch 2nd Ed (1873) Ballieres et Fils. Paris, Translated by F Gross

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Jean-Annet Bogros

Published: Friday, January 05, 2024 07:00 | Written by: Efrain A. Miranda, Ph.D. | Hits: 893

This article is part of the series "A Moment in History" where we honor those who have contributed to the growth of medical knowledge in the areas of anatomy, medicine, surgery, and medical research.

Jean-Annet Bogros (1786 - 1825) French physician, surgeon and anatomist. He was born in Bogros, a village in the mountains d’Auvergne, France.His family wanted him to become a priest, but his inclination towards medicine took him to an apprenticeship in the Hôtel-Dieu de Clermont, a hospital under the tutelage of Drs. Fleury, Lavort, and Bertrand. He continued his studies in Paris where he excelled at anatomy. He soon became an intern in Paris Hospitals, and in 1817 he became an assistant at the Faculty of Medicine. He was praised for his anatomical and surgical skills.

In August 29, 1823 he submitted his thesis for his Doctorate in Medicine “Essai Sur L’Anatomie Chirurgicale de la Region Iliaque: Et Description D’un Nouveau Procédure Pour Faire La Ligature Arteres Epigastrique Et Iliaque Externe”. His thesis challenged and improved the technique of ligation of the epigastric and iliac vessels proposed by Abernathy and Astley Cooper. His teaching rivaled the Astley Cooper technique, with an emphasis on hemostasis that was well recognized at the time.

Today his name is eponymically tied to the subinguinal space of Bogros, a triangular area posterior to the superior pubic ramus, lateral to the space of Retzius. This area is bound anteriorly by the deep preperitoneal fascia, and posteriorly by the peritoneum. The medial boundary of this space is either the lateral wall of the urinary bladder, or a sagittal plane passing at the origin of the inferior (deep) epigastric vessels. The superior boundary is the inguinal ligament, while the inferior and lateral boundaries are not described.

Bogros died in 1825 when he was 39 years of age. His cause of death in unknown, but many postulate tuberculosis.

Unfortunately, he was a good and simple man and was described as being meek and soft-spoken. Because of this, he only left one posthumous publication (1827) “Mémoire sur la Structure des Nerfs” where he explains a novel system to inject and identify nerves. This publication, in French, can be read and downloaded here.

Some biographical articles wrongly show his name as Jean-Antoine Bogros, others change the name to Annet Jean Bogros. Both are not correct. In our research we could not find a portrait of Bogros, so we used the cover or his posthumous memoir on the structure of the nerves.

Sources:

1. “Totally Extraperitoneal Herniorrhaphy (TEP): Lessons Learned from Anatomical Observations” Xue-Lu Zhou; Jian-Hua Luo; Hai Huang, et al. Minimally Invasive Surgery 2021(1):5524986
2. "Crucial steps in the evolution of the preperitoneal approaches to the groin: An historical review" R.C. Read Hernia 2010. 15(1):1-5
3. "Retzius and Bogros Spaces: A Prospective Laparoscopic Study and Current Perspectives" Ansari, MM Annals of International Medical and Dental Research, 2017 Vol (3), Issue (5) 25-31
4. " The Preperitoneal Space in Hernia Repair" Lorenz, A et al. Front Surg (2022) Visceral Surgery Vol 9
5. "Essai Sur L’Anatomie Chirurgicale de la Region Iliaque:: Et Description D’un Nouveau Procede: Pour Faire La Ligature Arteres Epigastrique Et Iliaque Externe” J.A. Bogros Imprimerie de E. Duverger. 1827 Paris