Artery

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A Moment in History

Georg Eduard Von Rindfleisch
(1836 – 1908)

German pathologist and histologist of Bavarian nobility ancestry. Rindfleisch studied medicine in Würzburg, Berlin, and Heidelberg, earning his MD in 1859 with the thesis “De Vasorum Genesi” (on the generation of vessels) under the tutelage of Rudolf Virchow (1821 - 1902). He then continued as a assistant to Virchow in a newly founded institute in Berlin. He then moved to Breslau in 1861 as an assistant to Rudolf Heidenhain (1834–1897), becoming a professor of pathological anatomy. In 1865 he became full professor in Bonn and in 1874 in Würzburg, where a new pathological institute was built according to his design (completed in 1878), where he worked until his retirement in 1906.

He was the first to describe the inflammatory background of multiple sclerosis in 1863, when he noted that demyelinated lesions have in their center small vessels that are surrounded by a leukocyte inflammatory infiltrate.

After extensive investigations, he suspected an infectious origin of tuberculosis - even before Robert Koch's detection of the tuberculosis bacillus in 1892. Rindfleisch 's special achievement is the description of the morphologically conspicuous macrophages in typhoid inflammation. His distinction between myocardial infarction and myocarditis in 1890 is also of lasting importance.

Associated eponyms

"Rindfleisch's folds": Usually a single semilunar fold of the serous surface of the pericardium around the origin of the aorta. Also known as the plica semilunaris aortæ.

"Rindfleisch's cells": Historical (and obsolete) name for eosinophilic leukocytes.

Personal note: G. Rindfleisch’s book “Traité D' Histologie Pathologique” 2nd edition (1873) is now part of my library. This book was translated from German to French by Dr. Frédéric Gross (1844-1927) , Associate Professor of the Medicine Faculty in Nancy, France. The book is dedicated to Dr. Theodore Billroth (1829-1894), an important surgeon whose pioneering work on subtotal gastrectomies paved the way for today’s robotic bariatric surgery. Dr. Miranda.

Sources:
1. "Stedmans Medical Eponyms" Forbis, P.; Bartolucci, SL; 1998 Williams and Wilkins
2. "Rindfleisch, Georg Eduard von (bayerischer Adel?)" Deutsche Biographie
3. "The pathology of multiple sclerosis and its evolution" Lassmann H. (1999) Philos Trans R Soc Lond B Biol Sci. 354 (1390): 1635–40.
4. “Traité D' Histologie Pathologique” G.E.
Rindfleisch 2nd Ed (1873) Ballieres et Fils. Paris, Translated by F Gross

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Artery

Published: Thursday, September 25, 2014 07:00 | Written by: Efrain A. Miranda, Ph.D. | Hits: 7492

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UPDATED: The term [artery] evolved from two Greek words. The first one is [αέρα], meaning "air", and the second one is [terein], a verb meaning "to keep" or "to maintain"¹. [Artery] therefore means "to maintain or to keep air", which is furthest from what we know today! The reason is that initial observations on these structures happened in bodies after combat, or gladiators who had exsanguinated because of their wounds. The arteries were empty (full of air) or contained a mix of blood and air. Arteries were considered a type of windipe. In fact, the original anatomical term for trachea was that of [tracheartery], which means "the rough artery". We have learned since then the true function of the arteries, so the name was shortened to "trachea".

The modern definition of an artery is "a structure that takes blood away from the heart". The amount of oxygen within the vessel has no bearing on the definition; there are arteries that carry oxygenated blood and arteries that carry deoxygenated blood.

Histologically, an artery is composed of three layers. The external layer is called the "adventitia" or "tunica externa". It is composed mostly of connective tissue. The middle layer is called the "tunica media" and is composed by a varying number of elastic fibers and smooth muscle fibers arranged as shown in the image. The inner layer is called the "tunica intima". The inner portion of the tunica intima is called the endothelium.

Arteries that are closer to the heart have more elastic fibers in their tunica media. As we move further away from the heart arteries become smaller and increase the number of smooth muscle fibers. This is what histologists describe "elastic arteries" and "muscular arteries". The smallest muscular arteries are called "arterioles". Large arteries have their own blood supply, called the "vasa vasorum".

Sources:
1. "The ancient Hellenic and Hippocratic origins of head and brain terminology" Panourias IG, Stranjalis G, Stavrinou L, Sakas DE. Clin Anat 2012 Jul;25(5):548-581
2. Image: "Blausen Gallery 2014" - Wikiversity Journal of Medicine. DOI:10.15347/wjm/2014.010. ISSN 20018762. Licensed under Creative Commons Attribution 3.0 via Wikimedia Commons - Original image